Genomics England
GMS Panels
Panels
Genes and Entities

RET

ret proto-oncogene
OMIM: 164761
PanelMode of inheritanceDetails
11 panels
Green
in Adult solid tumours cancer susceptibility
Signed-off version 2.2
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown
Phenotypes
Multiple Endocrine Neoplasia
Green
in Childhood solid tumours
R-numbers: R359
Signed-off version 4.0
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown
Phenotypes
Multiple Endocrine Neoplasia, MEN2B 162300
Green
in DDG2P
Component of the following Super Panels:
  • - Paediatric disorders
Signed-off version 3.79
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown
Phenotypes
RENAL AGENESIS 191830, MULTIPLE ENDOCRINE NEOPLASIA IIB 162300
Green
in Endocrine neoplasia
R-numbers: R217
Signed-off version 3.0
MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
Phenotypes
MEN2-like spectrum, Multiple Endocrine Neoplasia Type 2: RET Gene Deletion/Duplication, Multiple endocrine neoplasia IIA, 171400, Endocrine Cancer, Multiple Endocrine Neoplasia
Green
in Familial hyperparathyroidism or hypocalciuric hypercalcaemia
R-numbers: R151
Signed-off version 3.2
MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
Phenotypes
Multiple endocrine neoplasia IIB (162300), Multiple endocrine neoplasia IIA (171400)/MEN3
Green
in Fetal anomalies
R-numbers: R21, R412
Signed-off version 3.122
BOTH monoallelic and biallelic, autosomal or pseudoautosomal
Phenotypes
RENAL AGENESIS, MULTIPLE ENDOCRINE NEOPLASIA IIB
Green
in Hirschsprung disease
R-numbers: R177
Signed-off version 1.0
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown
Phenotypes
Green
in Inherited phaeochromocytoma and paraganglioma excluding NF1
R-numbers: R223
Signed-off version 2.0
MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
Phenotypes
Multiple endocrine neoplasia IIA, 171400Medullary thyroid carcinoma, 155240Multiple endocrine neoplasia IIB, 162300Central hypoventilation syndrome, congenital, 209880Pheochromocytoma, 171300Renal agenesis, 191830{Hirschsprung disease, susceptibility to, 1}, 142623, Multiple Endocrine Neoplasia
Green
in Multiple endocrine neoplasia type 2
R-numbers: R218
Signed-off version 1.0
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown
Phenotypes
Green
in Paediatric pseudo-obstruction syndrome
R-numbers: R438
Signed-off version 1.0
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown
Phenotypes
{Hirschsprung disease, susceptibility to, 1}, 142623, {Hirschsprung disease, protection against}, 142623
Green
in Unexplained young onset end-stage renal disease
R-numbers: R257
Signed-off version 3.11
MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
Phenotypes
Multiple endocrine neoplasia IIB, 162300, Central hypoventilation syndrome, congenital, 209880, Multiple endocrine neoplasia IIA, 171400, Renal agenesis, 191830, {Hirschsprung disease, susceptibility to, 1}, 142623, Pheochromocytoma, 171300, Renal Adysplasia, Medullary thyroid carcinoma, 155240