Genomics England

NRAS

NRAS proto-oncogene, GTPase

Panel	Mode of inheritance	Details
Filter panels9 panels
Green in Adult solid tumours cancer susceptibility Signed-off version 2.2	MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown	Phenotypes Cardio-Facio-cutanenous syndrome, Noonan syndrome 6 613224, CFC Syndrome
Green in DDG2P Component of the following Super Panels: - Paediatric disorders Signed-off version 3.79	MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown	Phenotypes NOONAN SYNDROME TYPE 6 613224
Green in Fetal anomalies R-numbers: R21, R412 Signed-off version 3.122	MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown	Phenotypes NOONAN SYNDROME TYPE 6
Green in Growth failure in early childhood R-numbers: R147 Signed-off version 3.0	MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted	Phenotypes Noonan syndrome, CFC Syndrome, A restricted spectrum of NRAS mutations causes Noonan syndrome. (Nat Genet. 42: 27-29, 2010.), Noonan syndrome 6, Cardio-Facio-cutanenous syndrome
Green in Intellectual disability Component of the following Super Panels: - Childhood onset leukodystrophy - Hypotonic infant - Paediatric disorders R-numbers: R29 Signed-off version 5.343	MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted	Phenotypes Autoimmune lymphoproliferative syndrome type IV, 614470Noonan syndrome 6, 613224Epidermal nevus, somatic, 162900Thyroid carcinoma, follicular, somatic, 188470Colorectal cancer, somatic, 114500, NOONAN SYNDROME TYPE 6
Green in Mosaic skin disorders - deep sequencing R-numbers: R327 Signed-off version 2.0	MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted	Phenotypes Congenital melanocytic naevus syndrome, Melanocytic naevi, Noonan syndrome
Green in Paediatric or syndromic cardiomyopathy Component of the following Super Panels: - Unexplained death in infancy and sudden unexplained death in childhood R-numbers: R135 Signed-off version 3.44	MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted	Phenotypes CFC Syndrome, Noonan syndrome, Noonan syndrome 6, Noonan syndrome 6 613224, syndromic HCM, Cardio-Facio-cutanenous syndrome
Green in Pigmentary skin disorders R-numbers: R236 Signed-off version 3.0	MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted	Phenotypes Congenital melanocytic naevus syndrome, Melanocytic naevi, NOONAN SYNDROME 6, Noonan syndrome, NS6
Green in Primary lymphoedema R-numbers: R136 Signed-off version 3.0	MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown	Phenotypes Noonan syndrome 6 613224